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I'd definitely advise anyone thinking about this to do their research but the risk doesn't seem to be as large as often suggested. There was a large US study that showed no correlation between lifetime psychedelic use and mental health problems.

"[...] lifetime use of LSD, psilocybin, mescaline, or peyote, or past year use of LSD, was not associated with a higher rate of mental health problems."

https://www.nature.com/news/no-link-found-between-psychedeli... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747247/



“Life time use” and “one time use triggering latent psychological conditions” are very different. Of course those who use over a long period of time aren’t showing adverse conditions. The ones who were triggered stayed away.


From the linked article:

> Of those, 14% described themselves as having used at any point in their lives any of the three ‘classic’ psychedelics: LSD, psilocybin (the active ingredient in so-called magic mushrooms) and mescaline (found in the peyote and San Pedro cacti). The researchers found that individuals in this group were not at increased risk of developing 11 indicators of mental-health problems such as schizophrenia, psychosis, depression, anxiety disorders and suicide attempts.

Emphasis on "at any point in their lives".


“Life time use” != "use over a long period of time"

In epidemiological surveys, lifetime use == reports using at least once.


> In epidemiological surveys, lifetime use == reports using at least once.

Not necessarily. For smoking you need to smoke 100 cigarettes before qualifying for lifetime use.


100 cigarettes seems like a very low threshold, that’s 5 packs of 20, even moderate smokers (>10 per day) could go through 200 in a month.


> the risk doesn't seem to be as large as often suggested

The anti-depressant business model is genius: (a) They're sold at a very high price point, (b) they generally make you factually dependent for quite some time (and they're quite hard to quit). It's one of big pharma's preferred multi-billion cash cows.

Now you know who's interested in spreading fear, doubt and uncertainty regarding cheap and effective competing substances such as LSD and psilocybin. And this industry has the resources to effectively influence public discussion forums such as HN, Reddit, Slashdot, etc.


None of this is true.

Anti-depressant meds are very cheap. This is one of the problems of meds, they're much cheaper than a course of talking therapy.

They don't cause dependence.

Most people don't have problems coming off SSRIs, SNRIs, NASAs etc.

> And this industry has the resources to effectively influence public discussion forums such as HN, Reddit, Slashdot, etc.

You might want to read any of the posts dang has mad about accusing people of astroturfing: https://hn.algolia.com/?query=by:dang%20astroturfing&sort=by...

That's also in the guidelines: https://news.ycombinator.com/newsguidelines.html

> Don't accuse others of astroturfing or shillage. Email us and we'll look into it.


> They don't cause dependence.

You say that with such authority, but in my personal experience they can absolutely cause dependency. I've had long-lasting withdrawal effects from certain SSRIs that were both physically and mentally painful.


It's not just me saying it. It's anyone who works in dependency services.

Discontinuation effects exist, are unpleasant, require correct tapering, but are not dependency.


I understand the word "dependency" to be synonymous with what you're calling discontinuation effects. So, I think I agree with you now. Thanks for the following up with your clarification.


Yes, and also:

'Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population.'

https://www.ncbi.nlm.nih.gov/pubmed/25586402




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