Surprised at the low number of CherryPy posts in this thread. Not only is it a great framework, it supports Python3 out of the box. My stack:

- ubuntu/debian - apt ftw

- python 3

- haproxy - proxy

- nginx - w/ uwsgi

- cherrypy - framework that supports PY3

- sqlalchemy - orm and sql

- postgres - relational storage

- mongodb - "mandatory" NoSQL

- 0MQ - messaging