This study has a solid methodology, and concluded that microdosing positive effects look significantly similar to placebo.
Given psychedelic agonistic activity on the 5ht2b receptors, chronic use is advised against because of the possibility of significant injury to the heart.
Fen-phen, notorious for causing heart failure, had the same mechanism of action. Phentermine and its analogs are still in use, but fenfluramine was found to be lethally dangerous, because of significant agonistic activity at 5ht2b receptors.
It remains to be seen if the dose makes the poison, but chronic stimulation of the receptors would seem to be inadvisable, given that the benefits of microdosing aren't distinguishable from placebo, according to a well designed study.
Full, heroic doses every 6 months have a proven positive effect, so treat yourself to a trip under the right conditions if you're wanting a boost to creativity and calming of the inner chatter.
The work of Dr. David Nutt is phenomenal. He is an advocate for science and for ending the absurd war on drugs.
Johns Hopkins is doing stellar work as well, using extremely rigorous and institutionally impeccable methodology to investigate psychedelics as treatment for some of the most pernicious conditions affecting the human mind.
This study has a solid methodology, and concluded that microdosing positive effects look significantly similar to placebo.
Given psychedelic agonistic activity on the 5ht2b receptors, chronic use is advised against because of the possibility of significant injury to the heart.
Fen-phen, notorious for causing heart failure, had the same mechanism of action. Phentermine and its analogs are still in use, but fenfluramine was found to be lethally dangerous, because of significant agonistic activity at 5ht2b receptors.
It remains to be seen if the dose makes the poison, but chronic stimulation of the receptors would seem to be inadvisable, given that the benefits of microdosing aren't distinguishable from placebo, according to a well designed study.
Full, heroic doses every 6 months have a proven positive effect, so treat yourself to a trip under the right conditions if you're wanting a boost to creativity and calming of the inner chatter.
https://en.wikipedia.org/wiki/Fenfluramine
https://en.wikipedia.org/wiki/5-HT2B_receptor
https://www.hopkinsmedicine.org/news/newsroom/news-releases/...
The work of Dr. David Nutt is phenomenal. He is an advocate for science and for ending the absurd war on drugs.
Johns Hopkins is doing stellar work as well, using extremely rigorous and institutionally impeccable methodology to investigate psychedelics as treatment for some of the most pernicious conditions affecting the human mind.