Except that in his podcast he spreads a lot of bad science. I'd even call it misinformation. The work on Sirtuins role in health span and life span is, at most, inconclusive. Multiple studies on trans-resveratrol failed to show any improvement whatsoever (and yes, even when mixed with a fat to increase bioavailability). Maybe NMN does something, maybe not. It's not yet clear.
He states everything as facts while most of his own studies have never been successfully replicated, even disproven in some cases.
I'd take everything he says with a grain of salt. He's been called out multiple times by his peers, including his own friends like Matt Kaeberlein.
_Obviously_ until conclusive double blind controlled studies have been done, this is all hypothesis.
The science behind the "longevity clock check" with by testing methaliations seems legit though doesn't it? I'm just a dude on the internet so would love some advice from somebody in the field.
But if that test is real, then it's a mater of time now isn't it? We wouldn't need to wait decades for people to die off so we can prove anything, we can just test with this clock, and in a couple of years we'll have results. I for one am quite excited about the whole thing.
While in his book he is less so, I think he seems pretty straight forward on his podcast by what has been tested with what, and how dubious the science of the various claims is. He admits a lot about some mechanism that they have no idea how it works, just that it does in various model organisms.
Anyway fasting and exercise have been linked to longevity for literally millennia by various religions largely unconnected with each other. I gather that we're now just trying to understand the mechanisms how all of this actually works.
I personally am trying the things on myself that have been proven to not cause harm, and seeing how it affects me. For now I've settled on reduced sugar in my diet, cut out gluten, stoped doing breakfast, started excising and do an occasional (2-3 times a year 4+ days water fasting). Seems to have kept the gray out of my hair for now - a lot of the friends in my age group already have it. Will see how that "no lunch" affects to me. All anecdotal of course.
He’s done a lot for mainstream interest in gerontology and longevity research but it’s pretty clear at this point that he’s financially tied to his position, there are multiple companies worth millions that develop products based on his labs research.
So he’d rather block everyone who tries to challenge him on Twitter and claim certainty on his podcast than be objective about the data.
He states everything as facts while most of his own studies have never been successfully replicated, even disproven in some cases.
I'd take everything he says with a grain of salt. He's been called out multiple times by his peers, including his own friends like Matt Kaeberlein.