Omega-3 gets me a little 'wired' sometimes. It's a powerful nootropic. My brain fires on all cylinders because it's now in an optimal state and primed for solving problems. This is generally good, but also sort of annoying since sometimes I just want to chill out and not do anything productive for a day. Otherwise: take it, but avoid taking it, if problem solving is not on the plate.
Eh everyone is different. Some people have weird reactions, I can believe it might make someone feel simulated for some reason. It's probably not a common reaction though