I think we fundamentally disagree here. There might be some 20:20 hindsight way to completely avoid the opioid crisis (especially with the behavior of Purdue Pharma), but from my perspective if Fentanyl (or other potent synthetic opioid) reaches illicit manufacturing it almost always becomes a dominate force in the black market. The cost, strength, and ease of smuggling are big perks. Regulators have little impact on what black market drug labs produce.