I guess it's not serious in this case, as streaming audio is not very CPU-intensive, BUT I noticed that when I trained my ML model (basically 100% GPU usage) I could hear a noise in my M40Xs. I guess it's some MOBO/GPU insulation issue.
Most GPUs have some degree of coil whine, often under high or specific load. Even my PS5's has it in the menu of a particular game, I suspect they haven't capped the framerate for that menu.
My what-if joke was going to involve memcopy bringing up the dormant avx unit & causing some power fluctuations in the system. Which is like 99.9999999% a joke.