When we're talking about evolution (of something like a human, not a bacterium or fruit fly) you can basically ignore anything that's happened in the last 25,000 years as an irrelevant blink-of-the-eye, timescale-wise.
The speed of evolution is faster than you think. The reason for that is that mammals rely on sexual selection instead of random mutations. This means that the prevalence of a gene within a population can rapidly change from say 1% of the population to 60% of the population within a few generations.
Evolution can trivially happen within one generation. Just consider lactose tolerance. If it happens that the only source of food is milk for a substantial period, then anybody with lactose intolerance dies and the relevant genes can go from being rare to being 100% in the population.
I don’t know the vaccine evolution came very quickly and we arrived at DNA and RNA modification levels which are able to shape our further evolution for ever.
Last 100 years? Forget it.