We have a fairly sophisticated HTML5 based Cardiology viewer that completely fell apart when Chrome 22 shipped. It dynamically creates video objects and layers canvases on top for measurements. Worked perfect through version 21. In 22, playback is jittery, the browser stops responding, then eventually freezes where you can't even close the browser window. Other tabs are affected as well even though the process is supposed to be isolated (i.e. new tabs go completely black when trying to play video).

The issue isn't fixed in Canary. We are doing our best to isolate it and provide a bug report that demonstrates the issue outside of the production environment.